Beilstein J. Org. Chem.2015,11, 1060–1067, doi:10.3762/bjoc.11.119
, India 10.3762/bjoc.11.119 Abstract A novel and convenient method utilizing the Aubéreaction to access a new class of compounds that are similar to carbocyclic nucleosides is reported. The azido alcohol derived from Vince lactam undergoes the Aubéreaction with various cyclic ketones to give
: Aubéreaction; biological activity; carbocyclic nucleosides; cyclopentenylated lactams; cyclopentylated lactams; Introduction
One popular method for the synthesis of N-substituted lactams is the Aubéreaction [1][2][3][4]. Over the last few decades, this reaction has gained popularity and resulted in
the production of a variety of chemical structures and generated new techniques in chemistry [5][6][7][8][9][10]. Additionally, it was applied to the synthesis of different natural products of biological importance [11][12][13][14][15]. In the Aubéreaction, an intermolecular reaction takes place
PDF
Graphical Abstract
Scheme 1:
The Aubé reaction and its selected applications.